Like vampire powers, some weaknesses are shared by all vampires, and some are not. Vampires can typically be killed by fire, decapitation, or a stake through the heart, or any other form of extreme physical trauma to the head or heart.

Blessed holy symbols: examples: crucifixes, bibles, prayer beads, repel vampires, but only if they are blessed and the wielder has true faith. When pressed to or put close to a vampire's skin, the item heats up, then catches fire with a white-blue flame, so hot only a few seconds contact will result in a second degree burn - any longer and it gives 3rd degree burns and can get hot enough to melt the metal of the symbol. When not touching the vampire's flesh, the item glows a brilliant white, the glow of which hurts and damages vampire eyes. Silver: it can harm them and force them to heal almost as slowly as a human, but not necessarily kill them unless they are head or heart shots. Those may be fatal especially in younger vampires. The metal added to fresh wounds will make the scars permanent. Weapons without silver on or in them have no effect on vampires.

Holy water: it burns and corrodes their flesh like strong acid, leaving ugly, twisted scars of melted flesh. As soon as it touches them, their flesh starts to bubble and boil. Sunlight: exposure to sunlight causes them to burn. Only vampires with a specific power (day-walkers) or enough power or who are old enough, like Mr. Oliver, can be awake during the day but still, they generally need to be in a protected location, away from direct sunlight. Fire, Flame: vampires are highly combustible and will quickly burn to just ash. Flame is the only way to truly kill the rotting form of vampire.

Garlic is very strong to a vampire so they try to avoid it when possible but it does little harm.

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